منابع مشابه
Parvin-ILK
Integrin-linked kinase (ILK), PINCH and Parvin proteins form the IPP-complex that has been established as a core component of the integrin-actin link. Our recent genetic studies on Drosophila parvin, reveal that loss of function mutant defects phenocopy those observed upon loss of ILK or PINCH in the muscle and the wing, strengthening the notion that these proteins function together in the orga...
متن کاملFunctional analysis of α-Parvin in vivo
The focal adhesion (FA) protein α-Parvin (αPv) has been shown to regulate integrin signalingand integrin-actin linkage. Here we report that the conditional deletion of the αPv gene inkeratinocytes leads to impaired hair follicle (HF) morphogenesis, epidermal hyperplasia andmicro-blistering. Expression of integrin α6 was reduced on αPv-deficient keratinocytes,leading to defects i...
متن کاملFunctional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of b-parvin
Introduction Extracellular signaling is commonly mediated through mechanisms that rely on protein-protein interactions and protein phosphorylation. The dynamics of protein-protein interactions are often dependent on the activation of a particular signal transduction pathway. Even a single protein can affect various cellular functions by interacting with different partners in response to extrace...
متن کاملFunctional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Visualization and quantification of the dynamics of protein-protein interactions in living cells can be used to explore the macromolecular events involved in signal transduction processes. In this study, functional molecular imaging using a luciferase-based complementation method demonstrated how the integrin-linked kinase (ILK)-mediated protein complex controls downstream signals. The lucifera...
متن کاملParvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.
Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44936